Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides
نویسندگان
چکیده
منابع مشابه
MiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC
Objective(s):MiRNAs have been proposed to be key regulators of tumorigenesis, progression and metastasis. However, their effect and prognostic value in gastric cancer is still poorly known. Materials and Methods: Gastric cancer cell lines were cultured. Tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time PCR (qRT-PCR) analysis. The tissue microarrays (T...
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PURPOSE To better understand microRNA miR-21 function in carcinogenesis, we analyzed miR-21 expression patterns in different stages of colorectal cancer development using in situ hybridization (ISH). EXPERIMENTAL DESIGN Locked nucleic acid (LNA)/DNA probes and a biotin-free tyramide signal amplification system were used in ISH analyses of miRNA expression. Conditions for specific detection of...
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Pathogenesis of endometrial cancer has been connected with alterations of microRNA expression and in particular miR-205 up-regulation was consistently reported in this carcinoma. Presented study aimed to investigate if inhibition of miR-205 expression using LNA-modified-nucleotide would attenuate endometrial cancer cells proliferation in vitro and in vivo.In the course of the study we found tha...
متن کاملmir-493 suppresses the proliferation and invasion of gastric cancer cells by targeting rhoc
objective(s):mirnas have been proposed to be key regulators of tumorigenesis, progression and metastasis. however, their effect and prognostic value in gastric cancer is still poorly known. materials and methods: gastric cancer cell lines were cultured. tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time pcr (qrt-pcr) analysis. the tissue microarrays (tm...
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Objective: The annual incidence of cancer in the world is growing rapidly. The most important factor in the cure of cancers is their early diagnosis. miRNA, as a biomarker for early detection of cancer, has attracted a lot of attention. Methods: In this study, an electrochemical biosensor was developed to detect the amount of miR-106a, the biomarker of gastric cancer, by modifying a glass...
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ژورنال
عنوان ژورنال: BMC Molecular Biology
سال: 2018
ISSN: 1471-2199
DOI: 10.1186/s12867-018-0107-6